MMP9 and IGFBP1 Regulate Tumor Immune and Drive Tumor Progression in Clear Cell Renal Cell Carcinoma.

ABSTRACT: Immunotherapy is a novel approach and has been used in various diseases, especially in cancers. Recently, immunotherapy has gradually been used to treat advanced clear cell renal cell carcinoma (ccRCC) or metastatic ccRCC. However, the efficacy of immunotherapy is not satisfying due to the influence of the tumor microenvironment. In this study, we mainly focused on the abundance and function of tumor-infiltrating immune cells (TIICs). Monocyte and TNM stage were identified as independent prognostic factors via CIBERSORT and Cox regression analysis. Then, ccRCC patients were divided into high risk/TNM^highMonocytes^low cluster and low risk/TNM^lowMonocytes^high cluster. Further differential gene analysis, protein-protein interaction (PPI) network, and

SUBMITTER: Xu T 

PROVIDER: S-EPMC7974879 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature