Proteomic analysis reveals rotator cuff injury caused by oxidative stress.

ABSTRACT:

Background and aims

Rotator cuff tendinopathy is common and is related to pain and dysfunction. However, the pathological mechanism of rotator cuff injury and shoulder pain is unclear. Objective: to investigate the pathological mechanism of rotator cuff injury and shoulder pain, and screen out the marker proteins related to rotator cuff injury by proteomics.

Methods

Subacromial synovium specimens were collected from patients undergoing shoulder arthroscopic surgery. The experimental group were patients with rotator cuff repair surgery, and the control group were patients with habitual dislocation of the shoulder joint. Pathological examination was performed, and then followed by non-labeled quantitative proteomic detection. Finally, from analysis of the biological informatio

SUBMITTER: Yuan T 

PROVIDER: S-EPMC7975570 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature