Targeting the medulloblastoma: a molecular-based approach.

ABSTRACT:

Background

The lack of success of standard therapies for medulloblastoma has highlighted the need to plan a new therapeutic approach. The purpose of this article is to provide an overview of the novel treatment strategies based on the molecular characterization and risk categories of the medulloblastoma, also focusing on up-to-date relevant clinical trials and the challenges in translating tailored approaches into clinical practice.

Methods

An online search of the literature was carried out on the PubMed/MEDLINE and ClinicalTrials.gov websites about molecular classification of medulloblastomas, ongoing clinical trials and new treatment strategies. Only articles in the English language and published in the last five years were selected. The research was refined based on the b

SUBMITTER: Luzzi S 

PROVIDER: S-EPMC7975825 | biostudies-literature | 2020 Jun

REPOSITORIES: biostudies-literature