Gene therapies for high-grade gliomas: from the bench to the bedside.

ABSTRACT:

Background

Gene therapy is the most attractive therapeutic approach against high-grade gliomas (HGGs). This is because of its theoretical capability to rework gene makeup in order to yield oncolytic effects. However, some factors still limit the upgrade of these therapies at a clinical level of evidence. We report an overview of glioblastoma gene therapies, mainly focused on the rationale, classification, advances and translational challenges.

Methods

An extensive review of the online literature on gene therapy for HGGs was carried out. The PubMed/MEDLINE and ClinicalTrials.gov websites were the main sources. Articles in English published in the last five years were sorted according to the best match with the multiple relevant keywords chosen. A descriptive analysis of the c

SUBMITTER: Giotta Lucifero A 

PROVIDER: S-EPMC7975827 | biostudies-literature | 2020 Jun

REPOSITORIES: biostudies-literature