Designing and evaluating contextualized drug-drug interaction algorithms.

ABSTRACT:

Objective

Alert fatigue is a common issue with off-the-shelf clinical decision support. Most warnings for drug-drug interactions (DDIs) are overridden or ignored, likely because they lack relevance to the patient's clinical situation. Existing alerting systems for DDIs are often simplistic in nature or do not take the specific patient context into consideration, leading to overly sensitive alerts. The objective of this study is to develop, validate, and test DDI alert algorithms that take advantage of patient context available in electronic health records (EHRs) data.

Methods

Data on the rate at which DDI alerts were triggered but for which no action was taken over a 3-month period (override rates) from a single tertiary care facility were used to identify DDIs that were con

SUBMITTER: Chou E 

PROVIDER: S-EPMC7976224 | biostudies-literature | 2021 Jan

REPOSITORIES: biostudies-literature