Methylation and molecular profiles of ependymoma: Influence of patient age and tumor anatomic location.

ABSTRACT: Ependymomas are tumors of the central nervous system that can occur in patients of all ages. Guidelines from the World Health Organization (WHO) for the grading of ependymomas consider patient age, tumor resection range, tumor location and histopathological grade. However, recent studies have suggested that a greater focus on both tumor location and patient age in terms of transcriptomic, genetic, and epigenetic analyses may provide a more accurate assessment of clinical prognosis than the grading system proposed by WHO guidelines. The current study identified the differences and similarities in ependymoma characteristics using three different molecular analyses and methylation arrays. Primary intracranial ependymoma tissues were obtained from 13 Korean patients (9 adults and 4 children),

SUBMITTER: Cho HJ 

PROVIDER: S-EPMC7976387 | biostudies-literature | 2021 May

REPOSITORIES: biostudies-literature