Prospective observational study of SARS-CoV-2 infection, transmission and immunity in a cohort of households in Liverpool City Region, UK (COVID-LIV): a study protocol.

ABSTRACT:

Introduction

The emergence and rapid spread of COVID-19 have caused widespread and catastrophic public health and economic impact, requiring governments to restrict societal activity to reduce the spread of the disease. The role of household transmission in the population spread of SARS-CoV-2, and of host immunity in limiting transmission, is poorly understood. This paper describes a protocol for a prospective observational study of a cohort of households in Liverpool City Region, UK, which addresses the transmission of SARS-CoV-2 between household members and how immunological response to the infection changes over time.

Methods and analysis

Households in the Liverpool City Region, in which members have not previously tested positive for SARS-CoV-2 with a nucleic acid ampli

SUBMITTER: Setiabudi W 

PROVIDER: S-EPMC7977072 | biostudies-literature | 2021 Mar

REPOSITORIES: biostudies-literature