GATA-targeted compounds modulate cardiac subtype cell differentiation in dual reporter stem cell line.

ABSTRACT:

Background

Pharmacological modulation of cell fate decisions and developmental gene regulatory networks holds promise for the treatment of heart failure. Compounds that target tissue-specific transcription factors could overcome non-specific effects of small molecules and lead to the regeneration of heart muscle following myocardial infarction. Due to cellular heterogeneity in the heart, the activation of gene programs representing specific atrial and ventricular cardiomyocyte subtypes would be highly desirable. Chemical compounds that modulate atrial and ventricular cell fate could be used to improve subtype-specific differentiation of endogenous or exogenously delivered progenitor cells in order to promote cardiac regeneration.

Methods

Transcription factor GATA4-targeted c

SUBMITTER: Valimaki MJ 

PROVIDER: S-EPMC7977156 | biostudies-literature | 2021 Mar

REPOSITORIES: biostudies-literature