Genome-wide association study identifies new loci associated with risk of HBV infection and disease progression.

ABSTRACT:

Background

Recent studies have identified susceptibility genes of HBV clearance, chronic hepatitis B, liver cirrhosis, hepatocellular carcinoma, and showed the host genetic factors play an important role in these HBV-related outcomes.

Methods

Collected samples from different outcomes of HBV infection and performed genotyping by Affymetrix 500 k SNP Array. GCTA tool, PLINK, and Bonferroni method were applied for analysis of genotyping and disease progression. ANOVA was used to evaluate the significance of the association between biomarkers and genotypes in healthy controls. PoMo, F_ST, Vcftools and Rehh package were used for building the racial tree and population analysis. F_ST statistics accesses 0.15 was used as a threshold to detect the signature of se

SUBMITTER: Zeng Z 

PROVIDER: S-EPMC7977299 | biostudies-literature | 2021 Mar

REPOSITORIES: biostudies-literature