Risk factors for breast cancer development by tumor characteristics among women with benign breast disease.

ABSTRACT:

Background

Among women diagnosed with invasive breast cancer, 30% have a prior diagnosis of benign breast disease (BBD). Thus, it is important to identify factors among BBD patients that elevate invasive cancer risk. In the general population, risk factors differ in their associations by clinical pathologic features; however, whether women with BBD show etiologic heterogeneity in the types of breast cancers they develop remains unknown.

Methods

Using a nested case-control study of BBD and breast cancer risk conducted in a community healthcare plan (Kaiser Permanente Northwest), we assessed relationships of histologic features in BBD biopsies and patient characteristics with subsequent breast cancer risk and tested for heterogeneity of associations by estrogen receptor (ER) s

SUBMITTER: Figueroa JD 

PROVIDER: S-EPMC7977564 | biostudies-literature | 2021 Mar

REPOSITORIES: biostudies-literature