STING controls nociception via type I interferon signalling in sensory neurons.

ABSTRACT: The innate immune regulator STING is a critical sensor of self- and pathogen-derived DNA. DNA sensing by STING leads to the induction of type-I interferons (IFN-I) and other cytokines, which promote immune-cell-mediated eradication of pathogens and neoplastic cells^1,2. STING is also a robust driver of antitumour immunity, which has led to the development of STING activators and small-molecule agonists as adjuvants for cancer immunotherapy³. Pain, transmitted by peripheral nociceptive sensory neurons (nociceptors), also aids in host defence by alerting organisms to the presence of potentially damaging stimuli, including pathogens and cancer cells^4,5. Here we demonstrate that STING is a critical regulator of nociception through IFN-I signalling in peripheral

SUBMITTER: Donnelly CR 

PROVIDER: S-EPMC7977781 | biostudies-literature | 2021 Mar

REPOSITORIES: biostudies-literature