Quantification of Cystic Fibrosis Lung Disease with Radiomics-based CT Scores.

ABSTRACT:

Purpose

To develop radiomics-based CT scores for assessing lung disease severity and exacerbation risk in adult patients with cystic fibrosis (CF).

Materials and methods

This two-center retrospective observational study was approved by an institutional ethics committee, and the need for patient consent was waived. A total of 215 outpatients with CF referred for unenhanced follow-up chest CT were evaluated in two different centers between January 2013 and December 2016. After lung segmentation, chest CT scans from center 1 (training cohort, 162 patients [median age, 29 years; interquartile range {IQR}, 24-36 years; 84 men]) were used to build CT scores from 38 extracted CT features, using five different machine learning techniques trained to predict a clinical prognostic scor

SUBMITTER: Chassagnon G 

PROVIDER: S-EPMC7977785 | biostudies-literature | 2020 Dec

REPOSITORIES: biostudies-literature