Resection of cerebellar tumours causes widespread and functionally relevant white matter impairments.

ABSTRACT: Several diffusion tensor imaging studies reveal that white matter (WM) lesions are common in children suffering from benign cerebellar tumours who are treated with surgery only. The clinical implications of WM alterations that occur as a direct consequence of cerebellar disease have not been thoroughly studied. Here, we analysed structural and diffusion imaging data from cerebellar patients with chronic surgical lesions after resection for benign cerebellar tumours. We aimed to elucidate the impact of focal lesions of the cerebellum on WM integrity across the entire brain, and to investigate whether WM deficits were associated with behavioural impairment in three different motor tasks. Lesion symptom mapping analysis suggested that lesions in critical cerebellar regions were related to def

SUBMITTER: Gomes CA 

PROVIDER: S-EPMC7978119 | biostudies-literature | 2021 Apr

REPOSITORIES: biostudies-literature