Genetic scores for adult subcortical volumes associate with subcortical volumes during infancy and childhood.

ABSTRACT: Individual differences in subcortical brain volumes are highly heritable. Previous studies have identified genetic variants that underlie variation in subcortical volumes in adults. We tested whether those previously identified variants also affect subcortical regions during infancy and early childhood. The study was performed within the Generation R study, a prospective birth cohort. We calculated polygenic scores based on reported GWAS for volumes of the accumbens, amygdala, brainstem, caudate nucleus, globus pallidus, putamen, and thalamus. Participants underwent cranial ultrasound around 7 weeks of age (range: 3-20), and we obtained metrics for the gangliothalamic ovoid, a predecessor of the basal ganglia. Furthermore, the children participated in a magnetic resonance imaging (MRI) stu

SUBMITTER: Lamballais S 

PROVIDER: S-EPMC7978120 | biostudies-literature | 2021 Apr

REPOSITORIES: biostudies-literature