Structural abnormalities of cingulate cortex in patients with first-episode drug-naive schizophrenia comorbid with depressive symptoms.

ABSTRACT: Depressive symptoms are common in patients with first-episode psychosis. However, the neural mechanisms underlying the comorbid depression in schizophrenia are still unknown. The main purpose of this study was to characterize the structural abnormalities of first-episodes drug-naïve (FEDN) schizophrenia comorbid with depression by utilizing both volume-based and surface-based morphometric measurements. Forty-two patients with FEDN schizophrenia and 29 healthy controls were recruited. The 24-item Hamilton Depression Rating Scale (HAMD-24) was administrated to divide all patients into depressive patients (DP) and non-depressive patients (NDP). Compared with NDP, DP had a significantly larger volume and surface area in the left isthmus cingulate cortex and also had a greater volume in the lef

SUBMITTER: Wei GX 

PROVIDER: S-EPMC7978138 | biostudies-literature | 2021 Apr

REPOSITORIES: biostudies-literature