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Multimodal imaging improves brain age prediction and reveals distinct abnormalities in patients with psychiatric and neurological disorders.

ABSTRACT: The deviation between chronological age and age predicted using brain MRI is a putative marker of overall brain health. Age prediction based on structural MRI data shows high accuracy in common brain disorders. However, brain aging is complex and heterogenous, both in terms of individual differences and the underlying biological processes. Here, we implemented a multimodal model to estimate brain age using different combinations of cortical area, thickness and sub-cortical volumes, cortical and subcortical T1/T2-weighted ratios, and cerebral blood flow (CBF) based on arterial spin labeling. For each of the 11 models we assessed the age prediction accuracy in healthy controls (HC, n = 750) and compared the obtained brain age gaps (BAGs) between age-matched subsets of HC and patients with Alzheimer's disease (AD, n = 54), mild (MCI, n = 90) and subjective (SCI, n = 56) cognitive impairment, schizophrenia spectrum (SZ, n = 159) and bipolar disorder (BD, n = 135). We found highest age prediction accuracy in HC when integrating all modalities. Furthermore, two-group case-control classifications revealed highest accuracy for AD using global T1-weighted BAG, while MCI, SCI, BD and SZ showed strongest effects in CBF-based BAGs. Combining multiple MRI modalities improves brain age prediction and reveals distinct deviations in patients with psychiatric and neurological disorders. The multimodal BAG was most accurate in predicting age in HC, while group differences between patients and HC were often larger for BAGs based on single modalities. These findings indicate that multidimensional neuroimaging of patients may provide a brain-based mapping of overlapping and distinct pathophysiology in common disorders.

SUBMITTER: Rokicki J

PROVIDER: S-EPMC7978139 | biostudies-literature | 2021 Apr

REPOSITORIES: biostudies-literature

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Multimodal imaging improves brain age prediction and reveals distinct abnormalities in patients with psychiatric and neurological disorders.

Rokicki Jaroslav J Wolfers Thomas T Nordhøy Wibeke W Tesli Natalia N Quintana Daniel S DS Alnaes Dag D Richard Genevieve G de Lange Ann-Marie G AG Lund Martina J MJ Norbom Linn L Agartz Ingrid I Melle Ingrid I Naerland Terje T Selbaek Geir G Persson Karin K Nordvik Jan Egil JE Schwarz Emanuel E Andreassen Ole A OA Kaufmann Tobias T Westlye Lars T LT

Human brain mapping 20201219 6

The deviation between chronological age and age predicted using brain MRI is a putative marker of overall brain health. Age prediction based on structural MRI data shows high accuracy in common brain disorders. However, brain aging is complex and heterogenous, both in terms of individual differences and the underlying biological processes. Here, we implemented a multimodal model to estimate brain age using different combinations of cortical area, thickness and sub-cortical volumes, cortical and ...[more]

PMID: 33340180

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Project description:Delineating the neuropathological characteristics across psychiatric disorders is critical for understanding their pathophysiology. The purpose of this study was to investigate common and distinct brain functional abnormalities across psychiatric disorders by using functional stability, a recently developed dynamic functional connectivity approach. Resting-state functional magnetic resonance imaging data were collected from a transdisease sample of healthy controls (n = 115) and individuals with schizophrenia (SZ) (n = 47), bipolar disorder (BD) (n = 44), and attention deficit/hyperactivity disorder (ADHD) (n = 40). Functional stability of each voxel was calculated by measuring the concordance of dynamic functional connectivity over time. Differences in functional stability among the four groups were assessed voxel-wisely. Compared to healthy controls, individuals with SZ demonstrated a distributed pattern of higher functional stability in the bilateral inferior temporal gyrus yet lower stability in the bilateral calcarine sulcus and left insula; individuals with BD only manifested local higher stability in the left inferior temporal gyrus; no differences were found between ADHD and healthy individuals. Notably, individuals with SZ and BD had common higher functional stability in the left inferior temporal gyrus, whereas higher functional stability in the right inferior temporal gyrus and lower stability in the bilateral calcarine sulcus and left insula were unique abnormalities in individuals with SZ. Additionally, direct comparisons between disorders revealed that individuals with SZ showed lower functional stability in the right calcarine sulcus compared to those with BD and higher stability in the left inferior temporal gyrus compared to those with ADHD. However, no significant associations between functional stability and clinical symptoms were observed. Our findings suggest that the functional stability approach has the potential to be extended to the domain of psychiatry and encourage further investigations of shared and unique neuropathology of psychiatric disorders.

Dataset Information

Multimodal imaging improves brain age prediction and reveals distinct abnormalities in patients with psychiatric and neurological disorders.

Publications

Multimodal imaging improves brain age prediction and reveals distinct abnormalities in patients with psychiatric and neurological disorders.

Similar Datasets

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