Development and evaluation of a high performance T1-weighted brain template for use in studies on older adults.

ABSTRACT: Τhe accuracy of template-based neuroimaging investigations depends on the template's image quality and representativeness of the individuals under study. Yet a thorough, quantitative investigation of how available standardized and study-specific T1-weighted templates perform in studies on older adults has not been conducted. The purpose of this work was to construct a high-quality standardized T1-weighted template specifically designed for the older adult brain, and systematically compare the new template to several other standardized and study-specific templates in terms of image quality, performance in spatial normalization of older adult data and detection of small inter-group morphometric differences, and representativeness of the older adult brain. The new template was constructed wit

SUBMITTER: Ridwan AR 

PROVIDER: S-EPMC7978143 | biostudies-literature | 2021 Apr

REPOSITORIES: biostudies-literature