Early effects of ventilatory rescue therapies on systemic and cerebral oxygenation in mechanically ventilated COVID-19 patients with acute respiratory distress syndrome: a prospective observational study.

ABSTRACT:

Background

In COVID-19 patients with acute respiratory distress syndrome (ARDS), the effectiveness of ventilatory rescue strategies remains uncertain, with controversial efficacy on systemic oxygenation and no data available regarding cerebral oxygenation and hemodynamics.

Methods

This is a prospective observational study conducted at San Martino Policlinico Hospital, Genoa, Italy. We included adult COVID-19 patients who underwent at least one of the following rescue therapies: recruitment maneuvers (RMs), prone positioning (PP), inhaled nitric oxide (iNO), and extracorporeal carbon dioxide (CO₂) removal (ECCO₂R). Arterial blood gas values (oxygen saturation [SpO₂], partial pressure of oxygen [PaO₂] and of carbon dioxide [PaCO

SUBMITTER: Robba C 

PROVIDER: S-EPMC7978164 | biostudies-literature | 2021 Mar

REPOSITORIES: biostudies-literature