Itraconazole for COVID-19: preclinical studies and a proof-of-concept randomized clinical trial.

ABSTRACT:

Background

The antifungal drug itraconazole exerts in vitro activity against SARS-CoV-2 in Vero and human Caco-2 cells. Preclinical and clinical studies are required to investigate if itraconazole is effective for the treatment and/or prevention of COVID-19.

Methods

Due to the initial absence of preclinical models, the effect of itraconazole was explored in a clinical, proof-of-concept, open-label, single-center study, in which hospitalized COVID-19 patients were randomly assigned to standard of care with or without itraconazole. Primary outcome was the cumulative score of the clinical status until day 15 based on the 7-point ordinal scale of the World Health Organization. In parallel, itraconazole was evaluated in a newly established hamster model of acute SARS-CoV-2 infect

SUBMITTER: Liesenborghs L 

PROVIDER: S-EPMC7979145 | biostudies-literature | 2021 Apr

REPOSITORIES: biostudies-literature