Malawian children with chest-indrawing pneumonia with and without comorbidities or danger signs.

ABSTRACT:

Background

Children with comorbidities or danger signs are often excluded from trials evaluating pneumonia treatment.

Methods

We sought to investigate whether the percentage of children with chest-indrawing pneumonia cured at Day 14 was lower among those with HIV infection or exposure, malaria, moderate or severe acute malnutrition, or anemia enrolled in a prospective observational cohort study than among children without these comorbidities enrolled in a concurrent prospective randomized controlled trial evaluating duration of amoxicillin treatment in Lilongwe, Malawi.

Results

Children with chest-indrawing pneumonia and comorbidities but without danger signs did not have statistically significant higher treatment failure rates by Day 6 than those in the chest-indrawi

SUBMITTER: Ginsburg AS 

PROVIDER: S-EPMC7979154 | biostudies-literature | 2021 Mar

REPOSITORIES: biostudies-literature