Ectodermal‑neural cortex 1 affects the biological function of lung cancer through the MAPK pathway.

ABSTRACT: Ectodermal‑neural cortex 1 (ENC1), a highly expressed protein in lung cancer tissues, was identified from the Cancer Genome Atlas (TCGA) database. The objective of the present study was to examine the effects of ENC1 on the biological functions of lung cancer cells. For this purpose, the expression of ENC1 was examined by RT‑qPCR to compare mRNA expression levels between 28 lung cancer tissue samples and para‑cancerous tissue samples. The association between ENC1 expression and clinicopathological features was evaluated between the 2 tissue types. Using RT‑qPCR and western blot analysis, the expression of ENC1 was investigated in a normal lung cell line (16HBE) and 2 lung cancer cell lines (A549 and H1299). The effect of siRNA targeting ENC1 (si‑ENC1) on the proliferation of A549 and H1299

SUBMITTER: Wu C 

PROVIDER: S-EPMC7979257 | biostudies-literature | 2021 May

REPOSITORIES: biostudies-literature