Polygenic and environmental influences on the course of African Americans' alcohol use from early adolescence through young adulthood.

ABSTRACT: The study examined (a) whether alcohol use subgroups could be identified among African Americans assessed from adolescence through early adulthood, and (b) whether subgroup membership was associated with the interaction between internalizing symptoms and antisocial behavior polygenic risk scores (PRSs) and environmental characteristics (i.e., parental monitoring, community disadvantage). Participants (N = 436) were initially recruited for an elementary school-based prevention trial in a Mid-Atlantic city. Youths reported on the frequency of their past year alcohol use from ages 14-26. DNA was obtained from participants at age 21. Internalizing symptoms and antisocial behavior PRSs were created based on a genome-wide association study (GWAS) conducted by Benke et al. (2014) and Tielbeek et

SUBMITTER: Rabinowitz JA 

PROVIDER: S-EPMC7979305 | biostudies-literature | 2020 May

REPOSITORIES: biostudies-literature