Age-Dependent Heterogeneity in the Efficacy of Prophylaxis With Enoxaparin Against Catheter-Associated Thrombosis in Critically Ill Children: A Post Hoc Analysis of a Bayesian Phase 2b Randomized Clinical Trial.

ABSTRACT:

Objectives

We explored the age-dependent heterogeneity in the efficacy of prophylaxis with enoxaparin against central venous catheter-associated deep venous thrombosis in critically ill children.

Design

Post hoc analysis of a Bayesian phase 2b randomized clinical trial.

Setting

Seven PICUs.

Patients

Children less than 18 years old with newly inserted central venous catheter.

Interventions

Enoxaparin started less than 24 hours after insertion of central venous catheter and adjusted to anti-Xa level of 0.2-0.5 international units/mL versus usual care.

Measurements and main results

Of 51 children randomized, 24 were infants less than 1 year old. Risk ratios of central venous catheter-associated deep venous thrombosis with prophylaxis with enoxaparin

SUBMITTER: Faustino EVS 

PROVIDER: S-EPMC7979442 | biostudies-literature | 2021 Apr

REPOSITORIES: biostudies-literature