Inflammatory phenotype of depression symptom structure: A network perspective.

ABSTRACT:

Background

There has been increasing interest in classifying inflammatory phenotypes of depression. Most investigations into inflammatory phenotypes only have tested whether elevated inflammation is associated with elevated levels of depression symptoms, or risk for a diagnosis. This study expanded the definition of phenotype to include the structure of depression symptoms as a function of inflammation.

Methods

Network models of depression symptoms were estimated in a sample of 4157 adults (mean age = 47.6, 51% female) from the 2015-2016 National Health and Nutrition Examination Survey (NHANES). Analyses included comparisons of networks between those with elevated (C-reactive protein (CRP) values ≥ 3.0 mg/L; N = 1696) and non-elevated CRP (N = 2841) as well as moderated netw

SUBMITTER: Moriarity DP 

PROVIDER: S-EPMC7979456 | biostudies-literature | 2021 Mar

REPOSITORIES: biostudies-literature