Dynamic regulation of T_FH selection during the germinal centre reaction.

ABSTRACT: The germinal centre is a dynamic microenvironment in which B cells that express high-affinity antibody variants produced by somatic hypermutation are selected for clonal expansion by limiting the numbers of T follicular helper cells^1,2. Although much is known about the mechanisms that control the selection of B cells in the germinal centre, far less is understood about the clonal behaviour of the T follicular helper cells that help to regulate this process. Here we report on the dynamic behaviour of T follicular helper cell clones during the germinal centre reaction. We find that, similar to germinal centre B cells, T follicular helper cells undergo antigen-dependent selection throughout the germinal centre reaction that results in differential proliferative expansion and contra

SUBMITTER: Merkenschlager J 

PROVIDER: S-EPMC7979475 | biostudies-literature | 2021 Mar

REPOSITORIES: biostudies-literature