Presynaptic Kv3 channels are required for fast and slow endocytosis of synaptic vesicles.

ABSTRACT: Since their discovery decades ago, the primary physiological and pathological effects of potassium channels have been attributed to their ion conductance, which sets membrane potential and repolarizes action potentials. For example, Kv3 family channels regulate neurotransmitter release by repolarizing action potentials. Here we report a surprising but crucial function independent of potassium conductance: by organizing the F-actin cytoskeleton in mouse nerve terminals, the Kv3.3 protein facilitates slow endocytosis, rapid endocytosis, vesicle mobilization to the readily releasable pool, and recovery of synaptic depression during repetitive firing. A channel mutation that causes spinocerebellar ataxia inhibits endocytosis, vesicle mobilization, and synaptic transmission during repetitive fi

SUBMITTER: Wu XS 

PROVIDER: S-EPMC7979485 | biostudies-literature | 2021 Mar

REPOSITORIES: biostudies-literature