Elevated peripheral inflammation is associated with attenuated striatal reward anticipation in major depressive disorder.

ABSTRACT:

Background

Major depressive disorder (MDD) is the leading cause of years lived with disability worldwide, and up to 40% of individuals with MDD do not respond to current treatments. Studies suggest that peripheral inflammation plays an important role in the striatal mesolimbic dopamine pathway and corticostriatal reward circuitry in MDD. Although MDD patients show blunted striatal responses to reward, the link between degree of inflammation and attenuation of reward processing is unclear. We investigated whether MDD patients with elevated peripheral inflammation exhibit attenuated reward responses to enhance our understanding of MDD pathophysiology and develop more effective treatments for current non-responders.

Methods

MDD subjects varying on serum C-reactive protein (CRP)

SUBMITTER: Burrows K 

PROVIDER: S-EPMC7979507 | biostudies-literature | 2021 Mar

REPOSITORIES: biostudies-literature