Personality pathways to mortality: Interleukin-6 links conscientiousness to mortality risk.

ABSTRACT: Personality is associated consistently with mortality hazards, but the physiological pathways are not yet clear. Immune system dysregulation may be one such pathway due to its role in age-related morbidity and mortality. In this preregistered study, we tested whether interleukin-6 (IL-6) and C-reactive protein (CRP) mediated the associations between personality traits and mortality hazards. The sample included 957 participants (M ± SD = 58.65 ± 11.51 years; range = 35-86 years) from the Midlife in the United States Survey that had 14 years of follow-up. Higher conscientiousness was associated with lower mortality hazards, with each one standard deviation higher conscientiousness associated with a 35% lower mortality risk. IL-6, but not CRP, partially mediated this association, with IL-6 ac

SUBMITTER: O'Suilleabhain PS 

PROVIDER: S-EPMC7979517 | biostudies-literature | 2021 Mar

REPOSITORIES: biostudies-literature