A mechanosensitive peri-arteriolar niche for osteogenesis and lymphopoiesis.

ABSTRACT: Stromal cells in adult bone marrow that express leptin receptor (LEPR) are a critical source of growth factors, including stem cell factor (SCF), for the maintenance of haematopoietic stem cells and early restricted progenitors^1-6. LEPR⁺ cells are heterogeneous, including skeletal stem cells and osteogenic and adipogenic progenitors^7-12, although few markers have been available to distinguish these subsets or to compare their functions. Here we show that expression of an osteogenic growth factor, osteolectin^13,14, distinguishes peri-arteriolar LEPR⁺ cells poised to undergo osteogenesis from peri-sinusoidal LEPR⁺ cells poised to undergo adipogenesis (but retaining osteogenic potential). Peri-arteriolar LEPR⁺osteole

SUBMITTER: Shen B 

PROVIDER: S-EPMC7979521 | biostudies-literature | 2021 Mar

REPOSITORIES: biostudies-literature