The deubiquitinase (DUB) USP13 promotes Mcl-1 stabilisation in cervical cancer.

ABSTRACT: Protein ubiquitination is a critical regulator of cellular homeostasis. Aberrations in the addition or removal of ubiquitin can result in the development of cancer and key components of the ubiquitination machinery serve as oncogenes or tumour suppressors. An emerging target in the development of cancer therapeutics are the deubiquitinase (DUB) enzymes that remove ubiquitin from protein substrates. Whether this class of enzyme plays a role in cervical cancer has not been fully explored. By interrogating the cervical cancer data from the TCGA consortium, we noted that the DUB USP13 is amplified in ~15% of cervical cancer cases. We confirmed that USP13 expression was increased in cervical cancer cell lines, cytology samples from patients with cervical disease and in cervical cancer tissue. D

SUBMITTER: Morgan EL 

PROVIDER: S-EPMC7979541 | biostudies-literature | 2021 Mar

REPOSITORIES: biostudies-literature