FTO-mediated cytoplasmic m⁶A_m demethylation adjusts stem-like properties in colorectal cancer cell.

ABSTRACT: Cancer stem cells (CSCs) are a small but critical cell population for cancer biology since they display inherent resistance to standard therapies and give rise to metastases. Despite accruing evidence establishing a link between deregulation of epitranscriptome-related players and tumorigenic process, the role of messenger RNA (mRNA) modifications in the regulation of CSC properties remains poorly understood. Here, we show that the cytoplasmic pool of fat mass and obesity-associated protein (FTO) impedes CSC abilities in colorectal cancer through its N⁶,2'-O-dimethyladenosine (m⁶A_m) demethylase activity. While m⁶A_m is strategically located next to the m⁷G-mRNA cap, its biological function is not well understood and has not b

SUBMITTER: Relier S 

PROVIDER: S-EPMC7979729 | biostudies-literature | 2021 Mar

REPOSITORIES: biostudies-literature