Red blood cell mannoses as phagocytic ligands mediating both sickle cell anaemia and malaria resistance.

ABSTRACT: In both sickle cell disease and malaria, red blood cells (RBCs) are phagocytosed in the spleen, but receptor-ligand pairs mediating uptake have not been identified. Here, we report that patches of high mannose N-glycans (Man_5-9GlcNAc₂), expressed on diseased or oxidized RBC surfaces, bind the mannose receptor (CD206) on phagocytes to mediate clearance. We find that extravascular hemolysis in sickle cell disease correlates with high mannose glycan levels on RBCs. Furthermore, Plasmodium falciparum-infected RBCs expose surface mannose N-glycans, which occur at significantly higher levels on infected RBCs from sickle cell trait subjects compared to those lacking hemoglobin S. The glycans are associated with high molecular weight complexes and protease-resistant, lower mo

SUBMITTER: Cao H 

PROVIDER: S-EPMC7979802 | biostudies-literature | 2021 Mar

REPOSITORIES: biostudies-literature