Gut microbiota determines the social behavior of mice and induces metabolic and inflammatory changes in their adipose tissue.

ABSTRACT: The link between the gut microbiota and social behavior has been demonstrated, however the translational impact of a certain microbiota composition on stable behavioral patterns is yet to be elucidated. Here we employed an established social behavior mouse model of dominance (Dom) or submissiveness (Sub). A comprehensive 16S rRNA gene sequence analysis of Dom and Sub mice revealed a significantly different gut microbiota composition that clearly distinguishes between the two behavioral modes. Sub mice gut microbiota is significantly less diverse than that of Dom mice, and their taxa composition uniquely comprised the genera Mycoplasma and Anaeroplasma of the Tenericutes phylum, in addition to the Rikenellaceae and Clostridiaceae families. Conversely, the gut microbiota of Dom mice includes

SUBMITTER: Agranyoni O 

PROVIDER: S-EPMC7979825 | biostudies-literature | 2021 Mar

REPOSITORIES: biostudies-literature