Dietary restriction transforms the mammalian protein persulfidome in a tissue-specific and cystathionine γ-lyase-dependent manner.

ABSTRACT: Hydrogen sulfide (H₂S) is a cytoprotective redox-active metabolite that signals through protein persulfidation (R-SS_nH). Despite the known importance of persulfidation, tissue-specific persulfidome profiles and their associated functions are not well characterized, specifically under conditions and interventions known to modulate H₂S production. We hypothesize that dietary restriction (DR), which increases lifespan and can boost H₂S production, expands tissue-specific persulfidomes. Here, we find protein persulfidation enriched in liver, kidney, muscle, and brain but decreased in heart of young and aged male mice under two forms of DR, with DR promoting persulfidation in numerous metabolic and aging-related pathways. Mice lacking cystathionine γ-

SUBMITTER: Bithi N 

PROVIDER: S-EPMC7979915 | biostudies-literature | 2021 Mar

REPOSITORIES: biostudies-literature