Recruited macrophages that colonize the post-inflammatory peritoneal niche convert into functionally divergent resident cells.

ABSTRACT: Inflammation generally leads to recruitment of monocyte-derived macrophages. What regulates the fate of these cells and to what extent they can assume the identity and function of resident macrophages is unclear. Here, we show that macrophages elicited into the peritoneal cavity during mild inflammation persist long-term but are retained in an immature transitory state of differentiation due to the presence of enduring resident macrophages. By contrast, severe inflammation results in ablation of resident macrophages and a protracted phase wherein the cavity is incapable of sustaining a resident phenotype, yet ultimately elicited cells acquire a mature resident identity. These macrophages also have transcriptionally and functionally divergent features that result from inflammation-driven al

SUBMITTER: Louwe PA 

PROVIDER: S-EPMC7979918 | biostudies-literature | 2021 Mar

REPOSITORIES: biostudies-literature