Computationally approached inhibition potential of Tinospora cordifolia towards COVID-19 targets.

ABSTRACT: The recent emergence of novel coronavirus (SARS-CoV-2) has been a major threat to human society, as the challenge of finding suitable drug or vaccine is not met till date. With increasing morbidity and mortality, the need for novel drug candidates is under great demand. The investigations are progressing towards COVID-19 therapeutics. Among the various strategies employed, the use of repurposed drugs is competing along with novel drug inventions. Based on the therapeutic significance, the chemical constituents from the extract of Tinospora cordifolia belonging to various classes like alkaloids, lignans, steroids and terpenoids are investigated as potential drug candidates for COVID-19. The inhibition potential of the proposed compounds against viral spike protein and human receptor

SUBMITTER: Jena S 

PROVIDER: S-EPMC7980128 | biostudies-literature | 2021 Mar

REPOSITORIES: biostudies-literature