Exocrine Pancreatic Enzymes Are a Serological Biomarker for Type 1 Diabetes Staging and Pancreas Size.

ABSTRACT: Exocrine pancreas abnormalities are increasingly recognized as features of type 1 diabetes. We previously reported reduced serum trypsinogen levels and in a separate study, smaller pancreata at and before disease onset. We hypothesized that three pancreas enzymes (amylase, lipase, and trypsinogen) might serve as serological biomarkers of pancreas volume and risk for type 1 diabetes. Amylase, lipase, and trypsinogen were measured from two independent cohorts, together comprising 800 serum samples from single-autoantibody-positive (1AAb⁺) and multiple-AAb⁺ (≥2AAb⁺) subjects, individuals with recent-onset or established type 1 diabetes, their AAb-negative (AAb^-) first-degree relatives, and AAb^- control subjects. Lipase and trypsinogen wer

SUBMITTER: Ross JJ 

PROVIDER: S-EPMC7980193 | biostudies-literature | 2021 Apr

REPOSITORIES: biostudies-literature