Molecular switch architecture determines response properties of signaling pathways.

ABSTRACT: Many intracellular signaling pathways are composed of molecular switches, proteins that transition between two states-on and off Typically, signaling is initiated when an external stimulus activates its cognate receptor that, in turn, causes downstream switches to transition from off to on using one of the following mechanisms: activation, in which the transition rate from the off state to the on state increases; derepression, in which the transition rate from the on state to the off state decreases; and concerted, in which activation and derepression operate simultaneously. We use mathematical modeling to compare these signaling mechanisms in terms of their dose-response curves, response times, and abilities to process upstream fluct

SUBMITTER: Ghusinga KR 

PROVIDER: S-EPMC7980379 | biostudies-literature | 2021 Mar

REPOSITORIES: biostudies-literature