Genome wide association study of HTLV-1-associated myelopathy/tropical spastic paraparesis in the Japanese population.

ABSTRACT: HTLV-1-associated myelopathy (HAM/TSP) is a chronic and progressive inflammatory disease of the central nervous system. The aim of our study was to identify genetic determinants related to the onset of HAM/TSP in the Japanese population. We conducted a genome-wide association study comprising 753 HAM/TSP patients and 899 asymptomatic HTLV-1 carriers. We also performed comprehensive genotyping of HLA-A, -B, -C, -DPB1, -DQB1, and -DRB1 genes using next-generation sequencing technology for 651 HAM/TSP patients and 804 carriers. A strong association was observed in HLA class I (P = 1.54 × 10^-9) and class II (P = 1.21 × 10^-8) loci with HAM/TSP. Association analysis using HLA genotyping results showed tha

SUBMITTER: Penova M 

PROVIDER: S-EPMC7980450 | biostudies-literature | 2021 Mar

REPOSITORIES: biostudies-literature