Primary differentiated respiratory epithelial cells respond to apical measles virus infection by shedding multinucleated giant cells.

ABSTRACT: Measles virus (MeV) is highly infectious by the respiratory route and remains an important cause of childhood mortality. However, the process by which MeV infection is efficiently established in the respiratory tract is controversial with suggestions that respiratory epithelial cells are not susceptible to infection from the apical mucosal surface. Therefore, it has been hypothesized that infection is initiated in lung macrophages or dendritic cells and that epithelial infection is subsequently established through the basolateral surface by infected lymphocytes. To better understand the process of respiratory tract initiation of MeV infection, primary differentiated respiratory epithelial cell cultures were established from rhesus macaque tracheal and nasal tissues. Infection of these cult

SUBMITTER: Lin WW 

PROVIDER: S-EPMC7980467 | biostudies-literature | 2021 Mar

REPOSITORIES: biostudies-literature