Tinospora cordifolia chloroform extract inhibits LPS-induced inflammation via NF-κB inactivation in THP-1cells and improves survival in sepsis.

ABSTRACT:

Background

Tinospora cordifolia (Willd).Miers is a perennial climbing medicinal shrub that has been traditionally used for the treatment of chronic inflammatory ailments. Our previous pre- clinical studies on anti-inflammatory effects, proved that the chloroform extract of T. cordifolia (CETC) suppressed the LPS induced up-regulation of pro-inflammatory biomarkers, hence, further follow up study was carried out to evaluate whether CETC can exhibit a protective effect against LPS induced lethal endotoxemia in vivo and also to analyze the impact of CETC pre-treatment on the secretion of pro-inflammatory cytokines in vitro by THP-1 cells.

Methods

To corroborate our previous preclinical studies on inflammation, we investigated the mechanism of the anti-inflammatory effect of T.

SUBMITTER: Philip S 

PROVIDER: S-EPMC7980548 | biostudies-literature | 2021 Mar

REPOSITORIES: biostudies-literature