Associations between metabolites and pancreatic cancer risk in a large prospective epidemiological study.

ABSTRACT:

Objective

To assess whether prediagnostic metabolites were associated with incident pancreatic ductal adenocarcinoma (PDAC) in a prospective cohort study.

Design

We conducted an untargeted analysis of 554 known metabolites measured in prediagnostic serum (up to 24 years) to determine their association with incident PDAC in a nested case-control study of male smokers (372 matched case-control sets) and an independent nested case-control study that included women and non-smokers (107 matched sets). Metabolites were measured using Orbitrap Elite or Q-Exactive high-resolution/accurate mass spectrometers. Controls were matched to cases by age, sex, race, date of blood draw, and follow-up time. We used conditional logistic regression adjusted for age to calculate ORs and 95% CIs f

SUBMITTER: Stolzenberg-Solomon R 

PROVIDER: S-EPMC7980697 | biostudies-literature | 2020 Nov

REPOSITORIES: biostudies-literature