Bioinformatics analysis identified CDC20 as a potential drug target for cholangiocarcinoma.

ABSTRACT:

Background

Cholangiocarcinoma (CCA) is a malignancy that originates from bile duct cells. The incidence and mortality of CCA are very high especially in Southeast Asian countries. Moreover, most CCA patients have a very poor outcome. Presently, there are still no effective treatment regimens for CCA. The resistance to several standard chemotherapy drugs occurs frequently; thus, searching for a novel effective treatment for CCA is urgently needed.

Methods

In this study, comprehensive bioinformatics analyses for identification of novel target genes for CCA therapy based on three microarray gene expression profiles (GSE26566, GSE32225 and GSE76297) from the Gene Expression Omnibus (GEO) database were performed. Based on differentially expressed genes (DEGs), gene ontology and p

SUBMITTER: Sungwan P 

PROVIDER: S-EPMC7980698 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature