Blood neurofilament light concentration at admittance: a potential prognostic marker in COVID-19.

ABSTRACT:

Objective

To test the hypotheses that blood biomarkers for nervous system injury, serum concentrations of neurofilament light chain protein (NfL) and glial fibrillary acidic protein (GFAp) can serve as biomarkers for disease severity in COVID-19 patients.

Methods

Forty-seven inpatients with confirmed COVID-19 had blood samples drawn on admission for assessing serum biomarkers of CNS injury by Single molecule array (Simoa), NfL and GFAp. Concentrations of NfL and GFAp were analyzed in relation to symptoms, clinical signs, inflammatory biomarkers and clinical outcomes. We used multivariate linear models to test for differences in biomarker concentrations in the subgroups, accounting for confounding effects.

Results

In total, 21% (n = 10) of the patients were admitted to

SUBMITTER: Aamodt AH 

PROVIDER: S-EPMC7980743 | biostudies-literature | 2021 Oct

REPOSITORIES: biostudies-literature