MiR-22-3p/PGC1β Suppresses Breast Cancer Cell Tumorigenesis via PPARγ.
Ontology highlight
ABSTRACT:
SUBMITTER: Wang X
PROVIDER: S-EPMC7981180 | biostudies-literature | 2021
REPOSITORIES: biostudies-literature
Publications
miR-22-3p/PGC1<i>β</i> Suppresses Breast Cancer Cell Tumorigenesis via PPAR<i>γ</i>.
Wang Xuehui X Yao Zhilu Z Fang Lin L
PPAR research 20210312
In this study, we found that miR-22-3p expression was decreased in breast cancer (BC) cell lines and tissues. Overexpression of miR-22-3p inhibited the proliferation and migration of BC cells in vitro and in vivo, while depletion of miR-22-3p exhibited the opposite effect. Importantly, miR-22-3p could directly target PGC1<i>β</i> and finally regulate the PPAR<i>γ</i> pathway in BC. In conclusion, miR-22-3p/PGC1<i>β</i> suppresses BC cell tumorigenesis via PPAR<i>γ</i>, which may become a potenti ...[more]
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