Early pediatric chronic kidney disease is associated with brain volumetric gray matter abnormalities.

ABSTRACT:

Background

The impact of pediatric chronic kidney disease (pCKD) on the brain remains poorly defined. The objective of this study was to compare brain morphometry between children with early-stage pCKD and typically developing peers using structural magnetic resonance imaging (MRI).

Methods

The sample age range was 6-16 years. A total of 18 children with a diagnosis of pCKD (CKD stages 1-3) due to congenital anomalies of the kidney and urinary tract and 24 typically developing peers were included. Volumetric data from MRI and neurocognitive testing were compared using linear models including pCKD status, age, maternal education level, and socioeconomic status.

Results

Cerebellar gray matter volume was significantly smaller in pCKD, t₍₃₈₎ = -2.71, p = 0.01.

SUBMITTER: Solomon MA 

PROVIDER: S-EPMC7981243 | biostudies-literature | 2021 Feb

REPOSITORIES: biostudies-literature