Patterns of seizure spread in temporal lobe epilepsy are associated with distinct white matter tracts.

ABSTRACT:

Objective

It is commonly hypothesized that seizure spread patterns in patients with focal epilepsy are associated with structural brain pathways. However, this relationship is poorly understood and has not been fully demonstrated in patients with temporal lobe epilepsy. Here, we sought to determine whether directionality of seizure spread (DSS) is associated with specific cerebral white matter tracts in patients with temporal lobe epilepsy.

Methods

Thirty-three adult patients with temporal lobe epilepsy who underwent stereoelectroencephalography (sEEG) and magnetic resonance diffusion tensor imaging (MR-DTI) as part of their standard-of-care clinical evaluation were included in the study. DSS was defined as anterior-posterior (AP) or medial-lateral (ML) spread based upon sEE

SUBMITTER: Gleichgerrcht E 

PROVIDER: S-EPMC7981262 | biostudies-literature | 2021 Mar

REPOSITORIES: biostudies-literature