Measurement of Organ-Specific and Acute-Phase Blood Protein Levels in Early Lyme Disease.

ABSTRACT: Lyme disease results from infection of humans with the spirochete Borrelia burgdorferi. The first and most common clinical manifestation is the circular, inflamed skin lesion referred to as erythema migrans; later manifestations result from infections of other body sites. Laboratory diagnosis of Lyme disease can be challenging in patients with erythema migrans because of the time delay in the development of specific diagnostic antibodies against Borrelia. Reliable blood biomarkers for the early diagnosis of Lyme disease in patients with erythema migrans are needed. Here, we performed selected reaction monitoring, a targeted mass spectrometry-based approach, to measure selected proteins that (1) are known to be predominantly expressed in one organ (i.e., organ-specific blood p

SUBMITTER: Zhou Y 

PROVIDER: S-EPMC7981273 | biostudies-literature | 2020 Jan

REPOSITORIES: biostudies-literature