Effect of corpus callosum agenesis on the language network in children and adolescents.

ABSTRACT: The present study is interested in the role of the corpus callosum in the development of the language network. We, therefore, investigated language abilities and the language network using task-based fMRI in three cases of complete agenesis of the corpus callosum (ACC), three cases of partial ACC and six controls. Although the children with complete ACC revealed impaired functions in specific language domains, no child with partial ACC showed a test score below average. As a group, ACC children performed significantly worse than healthy controls in verbal fluency and naming. Furthermore, whole-brain ROI-to-ROI connectivity analyses revealed reduced intrahemispheric and right intrahemispheric functional connectivity in ACC patients as compared to controls. In addition, stronger functional c

SUBMITTER: Bartha-Doering L 

PROVIDER: S-EPMC7981296 | biostudies-literature | 2021 Apr

REPOSITORIES: biostudies-literature