Calendar age and puberty-related development of regional gray matter volume and white matter tracts during adolescence.

ABSTRACT:

Background

Adolescence is a critical time for brain development. Findings from previous studies have been inconsistent, failing to distinguish the influence of pubertal status and aging on brain maturation. The current study sought to address these inconsistencies, addressing the trajectories of pubertal development and aging by longitudinally tracking structural brain development during adolescence.

Methods

Two cohorts of healthy children were recruited (cohort 1: 9-10 years old; cohort 2: 12-13 years old at baseline). MRI data were acquired for gray matter volume and white matter tract measures. To determine whether age, pubertal status, both or their interaction best modelled longitudinal data, we compared four multi-level linear regression models to the null model (gener

SUBMITTER: Ando A 

PROVIDER: S-EPMC7981330 | biostudies-literature | 2021 Apr

REPOSITORIES: biostudies-literature